解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS:Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a representative adult Chinese population. METHODS:Thirty-nine participan...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.013
更新日期:2018-10-01 00:00:00
abstract::Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.008
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. METHODS:We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.cyto.2018.05.004
更新日期:2018-10-01 00:00:00
abstract::Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.01.003
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.04.025
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.01.009
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.04.017
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.019
更新日期:2018-08-01 00:00:00
abstract::It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.11.010
更新日期:2018-07-01 00:00:00
abstract::ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.12.003
更新日期:2018-07-01 00:00:00
abstract::Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.11.006
更新日期:2018-07-01 00:00:00
abstract::The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.02.021
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis. AIM:To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.003
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS:In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2018.02.009
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.10.007
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF)...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.09.020
更新日期:2018-03-01 00:00:00
abstract::Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2017.09.017
更新日期:2018-03-01 00:00:00
abstract::The aim of this research was to assess the relationship between plasma adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-α) levels and echocardiographic parameters of ventricular remodeling in patients with coronary artery disease, without acute myocardial infarction. The study population consisted of 49...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2018.01.002
更新日期:2018-03-01 00:00:00
abstract::Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.09.015
更新日期:2018-02-01 00:00:00
abstract::Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2017.12.016
更新日期:2018-02-01 00:00:00
abstract::Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.12.014
更新日期:2018-02-01 00:00:00
abstract::Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-κB and MAP pro-s...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2016.08.035
更新日期:2018-01-01 00:00:00
abstract::Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.025
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS:We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4+ or CD8+ lymphocytes. Enzyme linked i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.08.018
更新日期:2017-11-01 00:00:00
abstract::IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.005
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the ci...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2017.08.017
更新日期:2017-11-01 00:00:00
abstract::Since its first description in 1966, macrophage migration inhibitory factor (MIF) was found to play a critical role in inflammatory and immune responses as well as in disease pathogenesis especially in tumor pathogenesis and cancer progression. MIF is expressed in different cell types and is associated with many disea...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.06.006
更新日期:2017-09-01 00:00:00
abstract::Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.05.017
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES:This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS:H...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.06.004
更新日期:2017-09-01 00:00:00
abstract::The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10-30) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×107L. infantum proma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.02.010
更新日期:2017-07-01 00:00:00
abstract::Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2017.02.013
更新日期:2017-07-01 00:00:00
abstract::Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.03.015
更新日期:2017-05-01 00:00:00
abstract:AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.05.003
更新日期:2017-05-01 00:00:00
abstract::This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.12.026
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.11.016
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.12.019
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:New vessels are formed in response to stimuli from angiogenic factors, a process in which paracrine signaling is fundamental. OBJECTIVE:To investigate the cooperative paracrine signaling profile in response to Vascular Endothelial Growth Factor (VEGF) gene therapy in patients with coronary artery disease (C...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2016.12.005
更新日期:2017-03-01 00:00:00
abstract::Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.10.009
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:This work is focused on finding new markers that complement or diagnoses currently used towards improving knowledge histological and statistical aspects that allow us to predict the local stage carcinomas and to identify and understand all the factors related to the progression of this disease. MATERIALS AN...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2016.08.008
更新日期:2017-01-01 00:00:00